SIDS breakthrough

Researchers have uncovered a direct link between SIDS and a developmental abnormality in babies, especially in premature babies and in boys.

This is the first time a direct link has been established to cases of sudden infant death syndrome (SIDS).

International research involving the University of Adelaide uncovered the link, and it is believed this abnormality, in the brain's control of head and neck movement, breathing, heartbeat and the body's responses to deprivation of oxygen supply, could be the reason why some babies sleeping on their front are more at risk of SIDS.

The results of the study, which investigated 55 SIDS cases in the United States, are now published in the journal PLOS ONE.

"One of the reasons why SIDS is so devastating for families is that death often occurs with no warning and no obvious signs of illness," said Dr Fiona Bright, Research Associate in the Adelaide Medical School, University of Adelaide, who conducted her work at Harvard and Adelaide as part of her PhD studies.

"While the exact cause of death in SIDS has not been identified, multiple studies have pointed to a subset of SIDS babies that are not entirely 'normal' before death. These infants all seem to have some form of underlying vulnerability, exposing them to increased risk.

"Our studies have now discovered a significant abnormality within key regions of the brainstem in SIDS babies, specifically in parts of the brainstem that control breathing and movements of the head and neck. This abnormality is directly linked to SIDS cases," she said.

Substance P — the culprit

The abnormality is in the transmission in the brain of a neuropeptide, known as "substance P", and its binding with an associated neuroreceptor, "neurokinin-1" (NK1R). Until now, worldwide investigations of the role of substance P in SIDS have been inconsistent and inconclusive.

"Substance P and the NK1R neuroreceptor play a critical role in the brain's control of the respiratory system, the cardiovascular system and in how the body responds to hypoxia — that is, deprivation of oxygen at the cell level," Dr Bright said.

"An infant with this abnormality is likely to have impaired respiratory and motor responses to life-threatening challenges during sleep. While they may be otherwise healthy looking, there is an inability for that child's brain and body to respond appropriately to an event in which the child is deprived of oxygen in some way."

Avoid sleeping on front

Study supervisor Professor Roger Byard, Professor of Pathology at the University of Adelaide, said this abnormality is a key reason why it is more dangerous for babies to sleep on their front.

"We've known for many years that babies sleeping face down places them at greater risk of SIDS — now we have a much better understanding as to why," Professor Byard said.

"If a child has this underlying vulnerability in its brain chemistry, and its breathing becomes compromised by sleeping on its front, that child is at greater risk of death because its body simply can't respond in the normal way. The baby can't lift its head, and its breathing and heartbeat will be compromised," he said.

The way forward

The study has shown that the abnormality in substance P is significantly influenced by prematurity and male sex, which may explain the increased risk of SIDS in premature and male infants.

"This demonstrated deficiency in substance P highlights that the problem in SIDS infants is much more complex than was once thought, and most likely involves the interactions of a number of chemicals, including serotonin," Dr Bright said.

"Ultimately, we hope that future research could lead to the development of screening techniques or biomarkers to identify infants who may be at risk of SIDS," she said.

The research was conducted by Dr Fiona Bright and Professor Roger Byard, Adelaide Medical School, University of Adelaide, in collaboration with Professor Hannah Kinney's lab at Harvard Medical School and Boston Children's Hospital.

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