Risk of Cardiovascular Disease in Women Reduced with Statin Therapy

A study comparing the effects of statin therapy between men and women has shown that the risk of cardiovascular disease in women is reduced when statin therapy is used.
Led by Professor Anthony Keech from the University of Sydney, the research confirms that statins are beneficial not only to women who have already had a cardiovascular event such as a heart attack or stroke, but also in those who at an increased risk of such diseases.
The study was published last week in  The Lancet.
"These results resolve a major uncertainty about the value of treating women with statin therapy, and reinforce the need for recommendations to treat women to be included in national and international guidelines," Professor Keech said.
"It has long been known that, by reducing low-density lipoprotein (LDL) cholesterol, statin medications prevent heart attacks and strokes in people at risk of these diseases. "However women tend to develop cardiovascular disease later in life than do men, so have been under-represented in most statin trials. As a result, the benefits of statin therapy in women have been uncertain, especially in the absence of any previous history of cardiovascular disease.
"This analysis of the effects of statins on 174,000 patients, undertaken by combining results from 27 different trials, shows beyond any reasonable doubt that women gain the same benefits from statins as men," he said.
Overall, statin treatment reduced the risk of a major vascular event (heart attack, stroke, bypass surgery, cardiac death) by 21 per cent for each 1 mmol/L reduction in LDL cholesterol achieved. The percentage risk reductions were similar in women and men, irrespective of any history of cardiovascular disease.
Such benefits from statin treatment translated into a significant reduction (9 per cent risk reduction for each 1 mmol/L reduction in LDL-cholesterol) in the overall risk of death in both men and women - a finding for women which has not been previously reported by any individual statin trial.
"There has been a recent worldwide shift towards recommending treatment with statins to people without existing cardiovascular disease but with a sufficiently high risk of future disease. The results of this study will reassure doctors that these risk-based guidelines for treatment can be applied to men and women equally," Professor Keech said.
Professor Len Kritharides, Chair of the Cardiovascular Health Advisory Committee of the Heart Foundation of Australia, welcomed these new results as very important: "They show unequivocally that statins similarly benefit men and women in preventing heart attacks without evidence of serious harm. Importantly, the study also demonstrates that treatment with statins improves overall survival in men and women. These results should give great encouragement to patients and their doctors that lowering cholesterol with statins prevents cardiovascular disease."
The study was an international meta-analysis conducted by the Cholesterol Treatment Trialists' Collaboration, a joint initiative coordinated between the NHMRC Clinical Trials Centre, University of Sydney, Australia and the Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), University of Oxford, United Kingdom, on behalf of academic researchers representing all major statin trials worldwide.
The work is funded by the Australian National Health and Medical Research Council (NHMRC), UK Medical Research Council (MRC), British Heart Foundation (BHF), and the European Community Biomed Program.