Herpes link to bipolar, depression

Patients experiencing severe depression and/or bipolar disorder are more likely to have brain cells infected by the human herpes virus.

The HHV-6 virus has been found in Purkinje neurons in the human cerebellum, the part of the brain that plays an important role in motor learning, fine motor control of the muscle, equilibrium and posture but also influences emotions, perception, memory and language.

The discovery was made by scientists from the Institute for Virology and Immunobiology of the University of Würzburg and their US colleagues, led by Dr Bhupesh Prusty, and published in Frontiers in Microbiology.

Virus-related inflammation in the brain

“Inherited factors have long been known to increase the risk of developing several types of psychiatric disorders including bipolar disorder, major depressive disorder and schizophrenia,” Prusty explained. But there is also strong evidence that environmental factors, particularly those that lead to neuroinflammation early in life, might play an important etiologic role in the pathogenesis of these disorders as well. Viruses are such an environmental factor.

“Pathogens may disrupt neurodevelopment and cross talk with the immune system at key developmental stages,” Prusty explained. Children that are infected at a young age usually recover without any late complications. However, the viruses lie dormant (latent) in various organs and tissues including the central nervous system and the salivary glands, and can be reactivated under certain circumstances, even after years.

Increased infection rate in two psychiatric disorders

Prusty and his team suspected the human herpes viruses HHV-6A and HHV-6B play a key role in the genesis of psychiatric disorders. So they studied two of the largest human brain biopsy cohorts from Stanley Medical Research Institute (USA) and what they found confirmed their assumption.

The results show for the first time that type HHV-6 viruses are capable of infecting neurons and possibly causing cognitive disturbances leading to mood disorder.

According to the scientists, the study disproves the belief that viruses which lie ‘dormant’ and hidden in organs and tissues never cause any disease. “Studies like ours prove this thinking as wrong,” Prusty said, and he cited another study which shows that Alzheimer’s disease can also be caused by human herpes virus 6A.

In the next step, the Würzburg researchers want to figure out the molecular mechanisms behind HHV-6A mediated cellular damage to Purkinje neurons.

Image credit: ©stock.adobe.com/au/John Gomez